Prevalence of Papillary Thyroid Carcinoma Difference in Pathologic Features and Tumor Capsule
Thyroid World Congress ePoster Library. Longoria-Dubocq T. 06/20/19; 271991; 190
Texell Longoria-Dubocq
Texell Longoria-Dubocq
Login now to access Regular content available to all registered users.

You may also access this content "anytime, anywhere" with the Free MULTILEARNING App for iOS and Android
Abstract
Rate & Comment (0)

Introduction: There is a recent shift toward performing a thyroid lobectomy in patients with a preoperative diagnosis of Papillary Thyroid Carcinoma (PTC) when certain criteria are met. PTC has a tumor capsule which can be intact, absent (AC), incomplete (ICC) or with invasion (CI) as described by the pathologist. The American Thyroid Association does not provide guidelines for the need of completion thyroidectomy when only these features are present1. While the prognostic significance of other unfavorable pathologic features have been evaluated, there is a scarcity of studies referring to tumor capsule status2,3. The purpose of our study is to evaluate the prevalence of different pathologic features related to the tumor capsule in patients with PTC. Methods: Retrospective study. Included patients with a final pathology of PTC. We then evaluated the pathologic features associated with tumor capsule and classified them into two subgroups: intact capsule (TC-), and altered capsule (TC+) which includes AC, ICC and CI. We then identified presence or absence of unfavorable features (UF+ or UF-) in each of the subgroups. UF are angio-lymphatic invasion, perineural invasion, extra thyroidal extension, multifocality, and lymph node metastasis. Results: 276 patients were included. Histologic presence of TC- and TC+ were 73.91% (204/276) and 26.09% (72/276), respectively. Prevalence of UF- within TC- and TC+ were of 41.67% (115/276) and 12.68% (35/276), respectively. In the TC+/UF- group, the most prevalent was AC 57.1% (20/35), reaching statistical significance with a p-value <0.01. Conclusion: Almost 13% of patients with PTC can present with only an altered capsule finding on permanent pathology. This group of patients deserves to be further studied to determine optimal management.


Introduction: There is a recent shift toward performing a thyroid lobectomy in patients with a preoperative diagnosis of Papillary Thyroid Carcinoma (PTC) when certain criteria are met. PTC has a tumor capsule which can be intact, absent (AC), incomplete (ICC) or with invasion (CI) as described by the pathologist. The American Thyroid Association does not provide guidelines for the need of completion thyroidectomy when only these features are present1. While the prognostic significance of other unfavorable pathologic features have been evaluated, there is a scarcity of studies referring to tumor capsule status2,3. The purpose of our study is to evaluate the prevalence of different pathologic features related to the tumor capsule in patients with PTC. Methods: Retrospective study. Included patients with a final pathology of PTC. We then evaluated the pathologic features associated with tumor capsule and classified them into two subgroups: intact capsule (TC-), and altered capsule (TC+) which includes AC, ICC and CI. We then identified presence or absence of unfavorable features (UF+ or UF-) in each of the subgroups. UF are angio-lymphatic invasion, perineural invasion, extra thyroidal extension, multifocality, and lymph node metastasis. Results: 276 patients were included. Histologic presence of TC- and TC+ were 73.91% (204/276) and 26.09% (72/276), respectively. Prevalence of UF- within TC- and TC+ were of 41.67% (115/276) and 12.68% (35/276), respectively. In the TC+/UF- group, the most prevalent was AC 57.1% (20/35), reaching statistical significance with a p-value <0.01. Conclusion: Almost 13% of patients with PTC can present with only an altered capsule finding on permanent pathology. This group of patients deserves to be further studied to determine optimal management.


    This eLearning portal is powered by:
    This eLearning portal is powered by MULTIEPORTAL
Anonymous User Privacy Preferences

Strictly Necessary Cookies (Always Active)

MULTILEARNING platforms and tools hereinafter referred as “MLG SOFTWARE” are provided to you as pure educational platforms/services requiring cookies to operate. In the case of the MLG SOFTWARE, cookies are essential for the Platform to function properly for the provision of education. If these cookies are disabled, a large subset of the functionality provided by the Platform will either be unavailable or cease to work as expected. The MLG SOFTWARE do not capture non-essential activities such as menu items and listings you click on or pages viewed.


Performance Cookies

Performance cookies are used to analyse how visitors use a website in order to provide a better user experience.


Save Settings