Long Standing Goitre as a risk of thyroid malignancy, review of 160 cases
Thyroid World Congress ePoster Library. Ahmed M. 06/21/19; 272006; 27
Mohamed Ahmed
Mohamed Ahmed
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Abstract
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Background: Goitre is endemic in Sudan. Patients present late and most physicians tend to prescribe long term thyroxin therapy . Surgical treatment is resolved to when pressure symptoms are eminent. The reported global risk of malignancy in long standing goitre was 2 - 3%,
Objective: To report on the risk of malignancy in long standing goitre exceeding 10 years .
Methods: All patients who underwent total thyroidectomy for goitre exceeding 10 years in Khartoum Teaching Hospital and Fedail Hospital during the period march 2017 to September 2018 were included.
Results 160 patients were studied, 28 males (18%) and 132 females (82.0%),with male to female ratio of 1.0:4.5. Age ranged between 19 and 81 years with mean age of 52.+13SD.
Twenty eight patients (17.5%) had recurrent goitre,.
A hundred and thirty one patients were euthyroid (81.9%), 22 hyperthyroid (13.8%) and 7 hypothyroid (4.4%) . Pressure symptoms were present in 151 patients (94.4%0). 76 had retrosternal extension as evidenced by thoracic inlet x-ray in 119 patients (74.4%) and CT scan in 41 patients ( 25.6%). All goitres were delivered via cervical approach and no sternotomy was needed.
Forty four patients (27.5 %) had malignant goitre and another 10 non suspicious proved to be malignant (9% incidental malignancy),
Histopathology showed 106 were simple nodular goitre (67.5%) and 54 were malignant (32.5%)..
Conclusion: Long standing goiter has a greater risk of malignant transformation and total thyroidectomy to be recommended for long standing simple goitre.
Background: Goitre is endemic in Sudan. Patients present late and most physicians tend to prescribe long term thyroxin therapy . Surgical treatment is resolved to when pressure symptoms are eminent. The reported global risk of malignancy in long standing goitre was 2 - 3%,
Objective: To report on the risk of malignancy in long standing goitre exceeding 10 years .
Methods: All patients who underwent total thyroidectomy for goitre exceeding 10 years in Khartoum Teaching Hospital and Fedail Hospital during the period march 2017 to September 2018 were included.
Results 160 patients were studied, 28 males (18%) and 132 females (82.0%),with male to female ratio of 1.0:4.5. Age ranged between 19 and 81 years with mean age of 52.+13SD.
Twenty eight patients (17.5%) had recurrent goitre,.
A hundred and thirty one patients were euthyroid (81.9%), 22 hyperthyroid (13.8%) and 7 hypothyroid (4.4%) . Pressure symptoms were present in 151 patients (94.4%0). 76 had retrosternal extension as evidenced by thoracic inlet x-ray in 119 patients (74.4%) and CT scan in 41 patients ( 25.6%). All goitres were delivered via cervical approach and no sternotomy was needed.
Forty four patients (27.5 %) had malignant goitre and another 10 non suspicious proved to be malignant (9% incidental malignancy),
Histopathology showed 106 were simple nodular goitre (67.5%) and 54 were malignant (32.5%)..
Conclusion: Long standing goiter has a greater risk of malignant transformation and total thyroidectomy to be recommended for long standing simple goitre.
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